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The NHS symptoms list groups them into general anaemia symptoms (tiredness, breathlessness, headaches, loss of appetite, weight loss) and neurological signs (peripheral neuropathy, balance problems, depression, memory and concentration changes, sometimes mood changes or psychosis in advanced cases)

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Mutations in DDHD2, encoding an intracellular phospholipase A1, cause a recessive form of complex hereditary spastic paraplegia

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